H2N2V1, PubMed, Checkpoint, bibRecord, 000175

Safety, immunogencity, and efficacy of a cold-adapted A/Ann Arbor/6/60 (H2N2) vaccine in mice and ferrets.

Identifieur interne : 000175 ( PubMed/Checkpoint ); précédent : 000174; suivant : 000176

Safety, immunogencity, and efficacy of a cold-adapted A/Ann Arbor/6/60 (H2N2) vaccine in mice and ferrets.

Auteurs : Grace L. Chen [États-Unis] ; Elaine W. Lamirande ; Hong Jin ; George Kemble ; Kanta Subbarao

Source :

Virology [ 1096-0341 ] ; 2010.

RBID : pubmed:20034647

Descripteurs français

KwdFr :
- Adaptation physiologique, Animaux, Basse température, Femelle, Furets, Infections à Orthomyxoviridae (), Infections à Orthomyxoviridae (virologie), Mutation, Mâle, Poumon (virologie), Réplication virale, Souris, Souris de lignée BALB C, Sous-type H2N2 du virus de la grippe A (génétique), Sous-type H2N2 du virus de la grippe A (immunologie), Vaccins antigrippaux (effets indésirables), Vaccins antigrippaux (immunologie), Vaccins atténués.
MESH :
- effets indésirables : Vaccins antigrippaux.
- génétique : Sous-type H2N2 du virus de la grippe A.
- immunologie : Sous-type H2N2 du virus de la grippe A, Vaccins antigrippaux.
- virologie : Infections à Orthomyxoviridae, Poumon.
- Adaptation physiologique, Animaux, Basse température, Femelle, Furets, Infections à Orthomyxoviridae, Mutation, Mâle, Réplication virale, Souris, Souris de lignée BALB C, Vaccins atténués.

English descriptors

KwdEn :
- Adaptation, Physiological, Animals, Cold Temperature, Female, Ferrets, Influenza A Virus, H2N2 Subtype (genetics), Influenza A Virus, H2N2 Subtype (immunology), Influenza Vaccines (adverse effects), Influenza Vaccines (immunology), Lung (virology), Male, Mice, Mice, Inbred BALB C, Mutation, Orthomyxoviridae Infections (prevention & control), Orthomyxoviridae Infections (virology), Vaccines, Attenuated, Virus Replication.
MESH :
- chemical , adverse effects : Influenza Vaccines.
- genetics : Influenza A Virus, H2N2 Subtype.
- immunology : Influenza A Virus, H2N2 Subtype, Influenza Vaccines.
- prevention & control : Orthomyxoviridae Infections.
- virology : Lung, Orthomyxoviridae Infections.
- Adaptation, Physiological, Animals, Cold Temperature, Female, Ferrets, Male, Mice, Mice, Inbred BALB C, Mutation, Vaccines, Attenuated, Virus Replication.

Abstract

We studied the attenuation, immunogenicity and efficacy of the cold-adapted A/Ann Arbor/6/60 (AA ca) (H2N2) virus in mice and ferrets to evaluate its use in the event of an H2 influenza pandemic. The AA ca virus was restricted in replication in the respiratory tract of mice and ferrets. In mice, 2 doses of vaccine elicited a >4-fold rise in hemagglutination-inhibition (HAI) titer and resulted in complete inhibition of viral replication following lethal homologous wild-type virus challenge. In ferrets, a single dose of the vaccine elicited a >4-fold rise in HAI titer and conferred complete protection against homologous wild-type virus challenge in the upper respiratory tract. In both mice and ferrets, the AA ca virus provided significant protection from challenge with heterologous H2 virus challenge in the respiratory tract. The AA ca vaccine is safe, immunogenic, and efficacious against homologous and heterologous challenge in mice and ferrets, supporting the evaluation of this vaccine in clinical trials.

DOI: 10.1016/j.virol.2009.12.003
PubMed: 20034647

Affiliations:

États-Unis

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Le document en format XML

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<front><div type="abstract" xml:lang="en">We studied the attenuation, immunogenicity and efficacy of the cold-adapted A/Ann Arbor/6/60 (AA ca) (H2N2) virus in mice and ferrets to evaluate its use in the event of an H2 influenza pandemic. The AA ca virus was restricted in replication in the respiratory tract of mice and ferrets. In mice, 2 doses of vaccine elicited a >4-fold rise in hemagglutination-inhibition (HAI) titer and resulted in complete inhibition of viral replication following lethal homologous wild-type virus challenge. In ferrets, a single dose of the vaccine elicited a >4-fold rise in HAI titer and conferred complete protection against homologous wild-type virus challenge in the upper respiratory tract. In both mice and ferrets, the AA ca virus provided significant protection from challenge with heterologous H2 virus challenge in the respiratory tract. The AA ca vaccine is safe, immunogenic, and efficacious against homologous and heterologous challenge in mice and ferrets, supporting the evaluation of this vaccine in clinical trials.</div>
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<Reference><Citation>Infect Immun. 1973 Jan;7(1):119-22</Citation>
<ArticleIdList><ArticleId IdType="pubmed">16558072</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>PLoS Pathog. 2007 Nov;3(11):e167</Citation>
<ArticleIdList><ArticleId IdType="pubmed">17997603</ArticleId>
</ArticleIdList>
</Reference>
<Reference><Citation>Virology. 1993 Jun;194(2):781-8</Citation>
<ArticleIdList><ArticleId IdType="pubmed">7684877</ArticleId>
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<name sortKey="Kemble, George" sort="Kemble, George" uniqKey="Kemble G" first="George" last="Kemble">George Kemble</name>
<name sortKey="Lamirande, Elaine W" sort="Lamirande, Elaine W" uniqKey="Lamirande E" first="Elaine W" last="Lamirande">Elaine W. Lamirande</name>
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   |clé=     pubmed:20034647
   |texte=   Safety, immunogencity, and efficacy of a cold-adapted A/Ann Arbor/6/60 (H2N2) vaccine in mice and ferrets.
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	Serveur d'exploration H2N2
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Serveur d'exploration H2N2

Safety, immunogencity, and efficacy of a cold-adapted A/Ann Arbor/6/60 (H2N2) vaccine in mice and ferrets.

Safety, immunogencity, and efficacy of a cold-adapted A/Ann Arbor/6/60 (H2N2) vaccine in mice and ferrets.

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